Hannibal, MO

united states

Hannibal sits on Mississippi River bluffs in northeast Missouri, famous as Mark Twain's boyhood home. Highway 61 runs north-south through downtown, connecting to I-72 for St. Louis access, while Highway 36 crosses east-west to Illinois. Most visitors come via these main routes to see Twain attractions. The Mark Twain Cave beneath the city stays 52 degrees year-round.